The current seismic resistance design lacks consideration for the life-cycle seismic performance of subway underground station, thus the finite element model of two-story and three-span underground subway station considering the corrosive conditions is established to investigate the corrosive influence on seismic performance of underground station in this study. By imposing the chlorine salt and air corrosive condition to the external (wall, bottom and top slab) and internal (middle slab and column) structure respectively, the time-dependent seismic performance of the two-story and three-span subway underground structure has been analyzed considering the different corrosion age. The results indicated that the seismic performance of the two-story and three-span subway underground structure would strengthen in the first 5 years, and then decline gradually. The inter-story drift ratios (IDR) of the structure does not exceed the range of corresponding seismic magnitude although the corrosive conditions are imposed to the structure, which means the life-cycle seismic performance of the structure meets the requirements. Moreover, the corrosion condition has more significant impact on the resistance of minor earthquake than moderate and major earthquake.