Plant hormones known as strigolactones (SLs) are crucial to many plant species’ environmental and developmental processes. It controls the symbiotic and parasitic interactions that mycorrhizal fungi, bacteria, and root parasite plants have with one another. It is well recognized that this class of endogenous phytohormones controls the morphology of the roots, secondary growth, and shoot branching. In the past few years, significant progress has been made in elucidating the function of strigolactones in plant growth, response to abiotic stressors, mesocotyl and stem elongation, secondary growth, and shoot gravitropism. Basic questions about SL biosynthesis and perception were explored with the use of several mutants from different plant species. Soil containing heavy metals (HMs) is a significant environmental issue that poses a threat to plants in a number of ways. SLs are linked to abiotic stressors like metals and nutrients, and they are essential to plants’ defense mechanisms against water and nutrient shortages. With the help of metals and nutrients, SLs activate bidirectional systems that affect the structure and activities of roots. In response to heavy metal pollution, such as Cd stress, plant extraction, and GR24 synthetic analog stimulation, SLs may play a significant role in regulating growth, root development, volume, architecture, and ROS scavenging. The function of SLs in reducing heavy metal stress was highlighted in this chapter.