Solid-solid mixing is a fundamental process utilized across numerous industries, yet a comprehensive understanding of granular material behavior remains elusive. The current study employs the Discrete Element Method (DEM) to explore the effect of radial segregation and its relation to variations in particle shape by using the multi-sphere approach. By generating four distinct types of binary mixtures, the investigation emphasizes the significant role of coarse particle shape in governing mixing and segregation dynamics within a rotating drum. The initial homogeneous mixture of coarse and fine particles evolves into radial segregation, marked by the aggregation of fine particles at the drum’s core, surrounded by coarser counterparts. Notably, the study unveils that spherical particles, whether act as coarse components in binary mixtures, tend to encourage segregation. Additionally, the study identifies that elongated needle-shaped particles exhibit relatively enhanced mixing behavior compared to spheres. This trend is consistent across both experimental and numerical simulations. The trend involves a sequential decrease in the segregation index value for coarse particles, with the order of shapes being sphere, followed by oblate, then prolate, and finally, elongated needle.