Blockchain and cryptocurrency is a significantly matured concept in advanced technology nowadays. This modern technology assures a decentralized economy system that allows valid transactions with safety and creates a transparent environment among members. Thus it is imperative to explore the actualization of blockchain across several domains where it had been ignored in the past. The acceptance and usability of blockchain and cryptocurrency enhances the implementation process that is analyzed through important factors. Here is classified the different blockchain application domains for research like supply chain management, finance, online education, governance, banking system, healthcare and construction areas. This research gives an overview of blockchain actualization from the perspective of end user; however the outcomes are helpful for all stakeholders. The results of this research will enhance the use of blockchain technology to develop relevant business. In addition, this study offers a multidisciplinary goal on blockchain and cryptocurrency research. The acceptance and usability of blockchain and cryptocurrency in India is outstandingly seen over recent years which encompasses different fields like waxing of public interest, technological advancements and regulatory developments. The approach of blockchain adoption in India is not liberated from skepticism and ambiguity, yet it developed inside an acceptable position gradually. This paper shows the role of blockchain technology in different application areas and focuses on the benefit of cryptocurrency which is expected to enhance the acceptance of this technology amongst the people in Indian context.