The unique properties of MXenes have garnered significant research interest for novel applications. However, the high-volume production processes in conventional large-scale manufacturing face significant challenges due to the use of non-bio-friendly, often toxic chemicals. These processes typically involve solid-state reactions at elevated temperatures and ongoing selective etching. Their uses are heavily contingent upon the production methods employed, necessitating experimental approaches to MXene production. Strategic synthetic approaches for the development of safer and more sustainable MXenes are essential for future market availability at competitive prices. This article aims to consolidate various advancements in environmentally friendly MXene synthesis methods, as evidenced by the increasing number of publications addressing non-hazardous materials. MXenes possess high surface areas, hydrophilicity, and other advantageous physicochemical properties that enhance their utility in drug delivery applications, particularly due to their capacity for substantial drug loading. Numerous biomedical applications of MXenes and their composites have been reported, with the majority of studies concentrating on two specific types: titanium carbide (Ti3C2) and tantalum Niobium (TaNb6) supported BMXs. MXene nanoparticles offer the advantage of controlled release in drug delivery systems by allowing the incorporation of various drugs and compounds into synthesized states. This approach has shown improvements in drug loading capacity, sustained-release profiles, and enhanced stability. In summary, MXene-based nanomaterials represent a promising framework for drug delivery, facilitating both the antibacterial and anticancer effects of pharmaceuticals. There is a limited number of studies comparing the efficacy of various synthetic routes in enhancing green synthesis and medical applications. The existence of this disparity highlights the necessity of conducting targeted research on the properties of MXene, their interactions with pharmaceuticals, as well as their long-term sustainability in biological systems and their impact on the environment.