MXenes, a rapidly emerging class of two-dimensional (2D) transition metal carbides and nitrides, have garnered significant attention for their unique physicochemical properties and exceptional catalytic performance. This paper discusses MXene-based catalysts that could promote the principles of green chemistry by the design of chemical processes, showing the potential to minimize and even eliminate hazardous substances in processes and their generation at any stage. This paper starts by introducing MXenes, their structure, and synthesis. It then proceeds to discuss properties with a particular focus on catalytic applications. It then elaborates on the applicability of MXenes in different catalytic reactions important for sustainable synthesis, such as organic transformations, environmental remediation, and energy conversion. Particular attention is given to the advantages MXenes offer over traditional catalysts, such as tunable surface chemistry, high electrical conductivity, and the ability to function under mild conditions, making them ideal candidates for green chemistry applications. Despite their promising capabilities, deploying MXene-based catalysts faces stability, scalability, and environmental impact challenges. These challenges, alongside emerging research directions, are critically examined to provide a balanced perspective on the future of MXenes in advancing green chemistry. The chapter concludes by highlighting the transformative potential of MXenes in catalysis and their role in achieving a more sustainable chemical industry.