Additive Manufacturing (AM) and Voronoi tessellation are a new dimension in material design and manufacturing, exploiting computational geometry to extract maximum structural performance from the material. This is done by the Voronoi decomposition of the design space into separate cellular regions based on proximity principles to create complex lightweight structures that exhibit enhanced mechanical properties. By strategically placing materials into interconnected polygonal cells via this technique, one may control the porosity, density, and mechanical response at microscopic scales. The relevant applications of this method are in the aerospace, biomedical, and advanced engineering fields where weight savings and very specific characteristic properties of material are crucial. Voronoi-based AM can generate metamaterials with customized mechanical responses, irregular geometric complexities, and optimum performance qualities, which cannot be manufactured by classical methods, through precision computational algorithms and sophisticated three-dimensional printing technology.