Solid particle transportation via pipelines has been a standard procedure for several industries, like the oil and gas, food, and pharmaceutical sectors. Especially in coal mining and ocean mining industries, large particles are transported using water as a medium through vertical pipes. The literature on the simulation of vertical slurry pipelines is found to be few, and the particle size used is in microns. Power consumption and pressure losses have remained a challenging issue in vertical pipes. Understanding vertical slurry flows is necessary because they have bigger pressure drops and higher losses than horizontal slurry flows. This work presents numerical modelling of a two-phase slurry flow in the vertical pipeline using ANSYS Fluent 17.2 software. Eulerian–Eulerian Approach is used to analyse slurry flow in vertical upward flow. A 3D model of 3.8 m long with 54.9 mm-diameter pipe is used for this analysis. Particle size 1–2 mm with density 2200 kg/m3 and viscosity 0.000017 Pa-s is considered. Simulations are conducted at 2 m/s slurry velocity with a solid volume fraction of 10%. The transient simulation is considered for this analysis. The kinetic theory of granular flow (KTGF) is used for the solid phase. Hexagonal non-uniform structured mesh is implemented with mesh refined near the boundary wall. Pressure drop is used as the primary parameter to analyse, and solid concentration profiles and velocity distribution profiles are also discussed in this study. The computational model and results presented in this work could be useful for simulating large particle slurry flows.