Microfluidics for point-of-care testing (POCT) allows for quick disease diagnosis, easy use, high sensitivity, on-site detection, and a simple format for obtaining results. Compared to existing technologies that require skilled personnel, centralized lab facilities, sample pre-treatment, and expensive instruments, microfluidic POCT offers advantages such as high throughput and low cost. However, it’s important to note that operating a microfluidic-based POCT may require an external pumping system, which limits its use in low-resource settings. A microactuator is created by mixing polydimethylsiloxane (PDMS), iron microparticles, and curing agents. The pump chamber is deformed by applying a magnetic field and temporarily collapses, sealing the chamber through the PDMS-iron macro composite. Moving a magnet along the chamber allows fluid to be pumped from the inlet to the outlet. These PDMS-iron macrocomposite-based microactuators are efficient, compact, low-power consumption, have impressive pumping capability, and are suitable for low-resource settings, showing great potential for microfluidics-based POCT devices.