Mass casualty incidents introduce significant challenges to healthcare systems. Although disaster training exercises are completed to enhance the response capabilities in hospitals, evaluating the effectiveness of these exercises is a challenging task that often requires subjective measures. This study aimed to develop a simulation model for the objective evaluation of disaster response performance in a large hospital setting. The model, refined through procedural modifications, accurately represents patient flow and task durations. Through a comparison of normative and descriptive scenarios, the gaps in disaster response performance were assessed, bottlenecks were identified, and improvements in preparedness were investigated. Furthermore, the results indicate that simulating normative scenarios provides optimal bed capacity and staff requirements, highlighting any areas for improvement to enhance the disaster response capabilities.