Advanced 3D-Printed Drug-Eluting Resorbable Implants and Fixation Devices
摘要
The field of medical implants has undergone significant transformation with the advent of 3D printing technology, particularly in the development of drug-eluting resorbable implants and fixation devices. These advanced implants not only provide essential mechanical support but also deliver therapeutic agents directly to the site of injury, offering a dual-functional approach to treatment. This chapter provides a comprehensive overview of the latest advancements in 3D-printed drug-eluting resorbable implants, detailing the materials used, including biodegradable polymers and bioactive ceramics, and the fabrication techniques such as Fused Deposition Modeling (FDM), Selective Laser Sintering (SLS), and Stereolithography (SLA). The discussion extends to various drug loading and release mechanisms, including surface coating, encapsulation, and matrix incorporation, highlighting their effectiveness in promoting localized drug delivery and reducing systemic side effects. Clinical applications in orthopedic surgery, spinal fusion, and craniofacial reconstruction are examined, emphasizing the potential benefits of these implants in improving patient outcomes. Challenges related to biocompatibility, regulatory approval, and controlled drug release are also addressed, along with potential solutions and future directions for research and development. This chapter aims to provide a comprehensive understanding of the state of the art in 3D-printed drug-eluting resorbable implants and fixation devices, showcasing their role in advancing personalized medicine and enhancing surgical outcomes.