This chapter offers an outline of how the Yijing 易經 informed interpretations of nothingness and perfection in Chinese and early modern European discourses. Part one briefly traces the priority of nothingness in the Yijing commentaries of Wang Bi 王弼 and the later Neo-Confucian dyadic dynamic of limitless nothingness (wuji 無極) and the supreme ultimate (taiji 太極). Following Song-Ming era compilations, early modern European missionaries and intellectuals interpreted the Yijing in relation to their own cosmological, metaphysical, and theological models. Part two reexamines Leibniz's growing engagement with the Yijing and Chinese philosophy as a discourse on nothingness and perfection and its theological, ontological, and mathematical significance. Although Chinese influences in the formation of Leibniz's binary mathematics and first metaphysical principles of God and nothingness should not be exaggerated, they became interculturally entangled. Leibniz determined that ancient Chinese wisdom was closest to the truths of natural philosophy and theology because it conceived of the world not through matter but through the fundamental principles and dynamics of perfection and nothingness, expressed by 1 and 0. Leibniz identified his binary arithmetic, and specifically his metaphysical-theological interpretation of its meaning, with the dyadic progression of the Yijing’s hexagrams. Leibniz remained committed to a Christianizing interpretation. Since nothingness could not be generative by itself, it required a transcendent and active principle of perfection that he construed as the hidden truth of Chinese philosophy.