Nursing officers play a foremost role in providing palliative care, and the notch of their mastery of this knowledge is essential to whether they can effectively deliver the epitome of palliative care. Because they spend a lot of time with patients and carry out vital tasks within the care team. The aim of this study was to evaluate nursing officers’ attitudes and knowledge on Palliative care. In order to measure the knowledge and attitudes of 128 nursing officers at a tertiary care setting, a cross-sectional study was carried out exploiting questionnaires. Chi-square testing, descriptive statistics, and convenience sampling were employed in the analysis. Participants’ average age was 30.6 ± 5.77 years, and their average experience was 8.1 ± 3.96 years. Just 17.1% had received PC-related training, and the bulk (82.81%) had no prior PC experience. There was diminutive knowledge (M = 9.2), but attitudes toward dying patients were moderate (M = 78.6). In conclusion despite low knowledge levels, many nursing officers maintain a favorable attitude toward palliative care, this study highlights a significant gap in palliative care knowledge among registered nurses. Improving the quality of palliative care services provided to patients requires enhancing nursing officer’s knowledge through periodic training education and on-the-job.