Globally, one of the main causes of maternal mortality is suicide. Suicide risk may be higher among South Asian women in the perinatal period. Perinatal women are especially vulnerable to mental health conditions, including depression and anxiety, which are closely associated with suicidal thoughts and behavior as well as self-harm, due to increased psychological, physiological, social, and cultural stressors. Complicated family dynamics and social pressure to have a male child, a lack of autonomy, low social standing, systematic discrimination, gender disparity, financial dependence, domestic and intimate partner violence, and a lack of opportunities and education are significant risk factors. Furthermore, risk is increased by obstacles to mental healthcare, such as stigma, a lack of mental health literacy, and difficult access to resources. There is an urgent need for more research and comprehensive suicide prevention programs to address the particular difficulties that South Asian women confront throughout their prenatal years. South Asian nations can significantly reduce suicidality during the perinatal period by strengthening their legal protections and healthcare systems, expanding access to mental healthcare, and encouraging suicide risk screening, psychosocial support programs, culture awareness, education, and economic empowerment.