Nanomaterial production is evolving with advanced techniques which are sometimes combined with sub-processes to develop stable and useful nanomaterials that can be compatible with diverse applications. Extrusion is one of the main nanomaterial production methods modified, scaled-down, and combined to fabricate nanomaterials in solid lipid nanoparticles, nanoemulsions, nanoparticles, liposomes, nanofibers, etc. Few classifications of nanomaterial extrusion were identified referring to literature. Among them, the hot-melt extrusion method can be identified as the classic version of extrusion. It was compacted from the plastic/rubber/food extruders for nanomaterial fabrication but innovative with advanced technologies to accommodate the favorable and critical conditions for nanomaterial production. Closely analyzing the technical aspects, for a proper nanoproduct with desired properties multi-factors are directly affected not only for the hot-melt extrusion but also for other extrusion methods referred. Therefore, for a particular type of nanomaterial fabrication for a particular application, the desired extrusion conditions are challenging to generalize. However, the trends in extrusion for nanomaterial production are being hiked toward more cutting-edge technologies.