Blockchain technology has revolutionized the safe processing of information and commerce that are required to decentralize methods applicable in various industries including financial services, health, and the Internet of Things. However, the ever-evolving quantum computing poses a tremendous challenge to blockchain’s basic cryptographic processes. Shor’s and Grover’s quantum types of algorithms possess classical cryptographic protocols namely digital signatures, as well as hashing functions, which provide security to blockchain-based transactions and data check summing. Such risk factors are, therefore, emerging as more realistic within quantum environments and consequently posing a strong requirement for blockchain systems to adjust security against quantum adversarial situations. Current work examines two primary approaches to achieving quantum-resilient blockchain security: The related concepts are post-quantum cryptography (PQC), and quantum-secured blockchain solutions. PQC lays emphasis over the specifications of the cryptography algorithm, which can be resilient against quantum attack, lattice-based, hash-based and multivariate polynomial. These methods help blockchain networks protect transactions with quantum-resistant encryption on classical hardware. On the other hand, QS-blockchain technologies employ quantum mechanics especially QKD to create theoretically invulnerable forms of communication. QKD ensures that participants in blockchains engage in the secure exchange of encryption keys, and such blockchains receive better protection from quantum attack by the opponents. The chapter also analyses some technical issues, such as the integration of PQC and QKD into blockchain architectures, the creation of a hybrid quantum–classical security concept, and establishing a structure for a Global Quantum Internet. Therefore, through the creation of quantum-resistant blockchain, interdisciplinary collaboration among cryptographers, blockchain developers and quantum researchers is created. Such a pragmatic strategy is crucial in order to maintain the safety and soundness of blockchain technology as advanced quantum risks appear over time, as well as to guarantee the system’s stability in the growing environment of digitalization and globalization.