The influence of rapid industrialization and human lifestyle excessive disposal of non-degradable pollutants occur particularly in industrial wastewaterWaste water, consequently posing health risk to both human and ecosystem. Even though many bioremediationBioremediation techniques can effectively remove dangerous pollutants, they basically require an understanding of the factors influencing the growth, metabolic rate, and native microbial consortia at the areas of contamination. In-depth understanding of the function and functional diversity of microbial cohorts as well as the fundamental processes in environmental bioremediationBioremediation has been made possible by the recent development of numerous cutting-edge and novel technologies, such as next-generation DNA sequencing, protein and metabolic profiling, and many more sophisticated tools. MetagenomicMetagenomic analysis combined with metabolomics and proteomicsProteomics provide a collective and comparative analysis of the potential microorganisms, paving way to further active participation in industrial wastewater treatment process. Since most of the potential bioremediationBioremediation mediating microbes are unculturable under standardized laboratory conditions, or even if they have shown positive results in-situ, their extensive application is limited ex-situ. Such potential drawback can be addressed by analysing collective database of microbial characteristics using multi-omics techniques. The omicsOmics frameworks in bioremediationBioremediation of developing pollutants in industrial wastewaterWaste water, as well as the efficacy of their holistic strategies for environmental sustainabilitySustainability and the bioeconomy, are therefore summarized and described in the current chapter.