Advancement in pharmacokinetics and pharmacogenomics has led to a conceptual change in the constantly evolving field of healthcare toward patient-centered care. The research of 3D printing technologies to personalize medicine to each patient’s needs has been encouraged by the necessity for customized therapies in light of this advancement. The pharmaceutical industry has been cautious to adopt personalized medicine (PM) despite its revolutionary potential, which has been hindered by this technological paradigm shift. A wide variety of 3D printing methods show potential for producing dosage forms and medical equipment, such as based on nozzle extrusion, laser writing systems, and powder binder jetting. From solid and semisolid formulations to locally administered or implanted medications, these techniques have employed in a wide range of areas. Better patient compliance and efficacy are made possible by solid dosage forms, which also allow for drug combination, release profile modification, and the production of innovative medicines. Joint replacements, prostheses, and cardiovascular procedures are accessible by sustained-release implants and medical equipment. Locally applied medications, such as medicated contact lenses and wound dressings, highlight how versatile 3D printing is in the medical field. But choosing appropriate printing methods and creating pharmaceutical inks with the right physicochemical and biological characteristics are the difficult parts. The promise of 3D printing in creating individualized medications for serious illnesses is encouraging, despite certain obstacles. Especially, developing a single dosage form that contains several medications has great promise for people with polypharmacy. This chapter presents an overview of 3D printing technology in customized medicine, highlighting its revolutionary role in influencing future of healthcare delivery by going over various processes, materials, and applications.