The growing need for customized pharmaceuticals and medical equipment has accelerated the influence of additive manufacturing in recent years. 3D printing has emerged as one of the most novel and powerful tools for precisely creating specifically designed dosage forms, tissue engineering, and disease modeling. The ability of 3D printing to generate pharmaceuticals with exact measurements tailored to particular patients’ requirements has demonstrated the feasibility of manufacturing personalized medicines in innovative dosage forms. The discovery enables a clear vision of dose structures on various forms, sizes, and surfaces, as well as the obstacles connected with delivering them under such planned settings. The dissolving patterns of active pharmaceutical ingredients (APIs) in pharmaceutical formulations have a substantial impact on their pharmacokinetic behavior. Current successes include multifunctional drug delivery systems with faster release, customizable and personalized dose forms, implants and phantoms modeled after individual patient anatomy, and cell-based materials for regenerative medicine. Unlike traditional production processes, 3DP technology enables exact control of the geometry, internal structure, and surface area that influence dissolution kinetics. The current chapter summarizes all the advanced techniques in various 3D printed dosage forms with limitations and challenges.