In this chapter, we seek an approach between agroecology and border thinking, emphasizing the cultivation of resilience. By means of a southern perspective, we show that agroecology may be a path that offer a life project based on rethinking the relationships among human beings and between humans and nature. In order to rethink sustainable ways of life, agroecology proposes the protagonism of those who live in the social contexts in which productive innovations will be implemented. This points out to agroecology as a project that favours the cultivation of resilience, understood here as a means to navigate a world of uncertainty. The proposal to build agroecological knowledge implies the transformation of power relations, breaking with the hierarchy of knowledge, which has the potential to build resilience not by returning a phenomenon to its original configuration before a specific impact. It is a proposal that understands the need for complex transformations involving social, economic and ecological dimensions rather than adaptations. To illustrate this, we bring the case of water access programmes in Brazil, showing how the participative processes conducted by local groups, instead of external interventions of “specialists”, brought impressive results for the reality in question.