Salinity is a significant threat to agriculture, posing a risk to global food security. Overcoming salinity with efficient and cost-effective solutions is imperative for sustainable agriculture, and the use of phytohormones is one such possibility. Salicylic acid (SA), a naturally occurring phenolic plant hormone, plays a crucial role as a signaling molecule to regulate growth and development. In the past two decades, the defensive role of salicylic acid against abiotic stress has gained much attention, and we have previously reported the role of salicylic acid in alleviating salt stress by maintaining water status, ion homeostasis, increase in the rate of photosynthesis, osmolyte accumulation, and reduction in oxidative damage by an increase in antioxidants. In this chapter, we focus on the membrane lipids with regard to the application of SA and its possible function in mitigating salt stress to increase crop productivity.