To meet the needs of large-capacity and high-quality development of wind turbines, further improve the stability and dynamic response performance of wind power output, and reduce the dynamic load of key components, a large-scale wind turbine adaptive PI-independent pitch control strategy considering load reduction is proposed. Based on the ROSCO controller, independent pitch control is implemented for the three blades of the wind turbine. Taking the 5 MW wind turbine of the National Renewable Energy Laboratory as an example, a model is built on the MATLAB simulation platform for simulation analysis and verification. The results show that compared to the unified pitch control strategy of the ROSCO controller, the proposed method can effectively suppress output power fluctuations, reduce tower loads of wind turbines, and have better adaptability to wind speed changes and fast response ability. Its advantages are more prominent in harsh wind conditions, such as turbulent wind.