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Biofilm formation by Salmonella typhi presents a series of public health challenges, intensified by rising antibiotic resistance and mortality rates. The ability of S. typhi to generate biofilms has rendered even potent antibiotics ineffective, contributing to the severity of typhoid fever, which is linked to other serious conditions such as gallbladder cancer. The virulence of this pathogen is attributed to the intricate interplay of various genes and proteins involved in biofilm development. This chapter focuses on biofilm formation and its mechanism with essential regulatory proteins. Additionally, this chapter also focuses on advanced therapy, which is an effective solution to control bacterial biofilm infections.

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Associations Between Typhoidal Infections and Bacterial Biofilms

  • 章节

  • 发表日期：

    2025年

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  • Anhik Pattanayak,
  • Aditya Upadhyay,
  • Awanish Kumar

摘要

Biofilm formation by Salmonella typhi presents a series of public health challenges, intensified by rising antibiotic resistance and mortality rates. The ability of S. typhi to generate biofilms has rendered even potent antibiotics ineffective, contributing to the severity of typhoid fever, which is linked to other serious conditions such as gallbladder cancer. The virulence of this pathogen is attributed to the intricate interplay of various genes and proteins involved in biofilm development. This chapter focuses on biofilm formation and its mechanism with essential regulatory proteins. Additionally, this chapter also focuses on advanced therapy, which is an effective solution to control bacterial biofilm infections.