The mental health impact of lipedema extends beyond the physical symptoms of the condition, deeply affecting patients’ emotional and psychological well-being. Patients with lipedema are at an increased risk of developing psychological disorders such as anxiety and depression, a vulnerability that can be exacerbated by underlying difficulties in emotion regulation (ER). For instance, Al-Wardat et al. (2022) found in their international survey of 1358 lipedema patients that 28% reported emotional lability, indicating a significant prevalence of rapid and exaggerated mood changes among those afflicted. This emotional instability suggests that a considerable number of individuals with lipedema struggle with ER, which involves controlling emotional experiences and expressions, as well as the ability to process a full spectrum of emotions adaptively. The challenges faced by lipedema patients, including accessing adequate healthcare, coping with unmanageable changes in body appearance, and dealing with weight stigma and social isolation, can lead to or exacerbate these ER difficulties.