Head-related product design is significantly enhanced by a thorough understanding of the morphological differences in human heads between genders. Existing head variation studies primarily focus on overall size and facial landmarks originating from facial recognition technologies, limiting the scope to facial features. Our research proposes a more comprehensive framework, establishing thirty distinct landmarks encompassing the entire head, utilizing Computed Tomography (CT) imaging to explore morphological diversity between genders in Malaysian adults. We divided the study group by gender to validate the precision of these landmarks in capturing morphologic variances, employing the Intraclass Correlation Coefficient (ICC) for reliability assessment. Through rigorous statistical analysis, the study examines the differences and correlations in head morphology between gender groups at anatomical landmark locations. The study offers valuable insights into the morphological variations in human heads, providing insights for further research in head-related product design and anthropological fields.