The response of curved reinforced concrete wall panel under a blast load scenario was investigated using the explicit dynamic finite element solver Abaqus/Explicit. The curved reinforced concrete panel was modeled using three-dimensional solid elements (C3D8R) while three-dimensional truss elements (T3D2) were used to model the steel reinforcements. The behavior of concrete was simulated using a concrete damaged plasticity constitutive model considering the nonlinearity of concrete material. Steel reinforcement behavior was simulated using metal plasticity with an isotropic-linear elasticity material model. The blast scenario was modeled utilizing the CONWEP function in Abaqus/Explicit. The effect of different key parameters such as different types of curvature, i.e., convex and concave, charge weight, and span to the radius of curvature (L/R) was investigated. The comparative response of the RC panel with and without curvature is presented as displacement time histories and damage evaluation in terms of tensile and compressive damage variables. It was revealed from the study that the displacement is considerably reduced by the introduction of convex curvature to a straight RC wall panel; however, increased span to the radius of curvature ratio considerably reduces the peak displacement irrespective of the type of curvature. On reviewing damage evolution, it is observed that tensile damage is considerably reduced due to a higher span to the radius of curvature ratio.