This study investigates the durability characteristics of ternary blended concrete incorporating industrial by-products, Ground Granulated Blast Furnace Slag (GGBFS) and Microfine (MF) as partial replacements for Ordinary Portland Cement (OPC) and Manufactured Sand (MS) as a replacement for river sand. The M30 grade concrete mixes were prepared using a control mix and a ternary blend (G3M4) of 30% GGBFS, 20% MF, and 50% OPC. Durability was assessed under acid (5% HCl + 5% H2SO4) and salt (10% NaCl) exposure conditions. Cube specimens were tested for compressive strength and weight reduction at intervals of 28, 56, 90, and 180 days. The results reveal that G3M4 exhibited significantly lower weight reduction factors (7.64% under acid exposure and 4.98% under saline exposure) than the control mix (12.99% and 5.35%, respectively). Similarly, G3M4 demonstrated enhanced resistance to compressive strength loss, with reductions of 45.41 and 6.88% under acid and salt exposure, respectively, compared to 52.08 and 9.44% for the control mix. These improvements are attributed to the denser microstructure and enhanced chemical resistance provided by GGBFS and MF. The findings confirm that ternary blended concrete with MS can achieve superior durability in aggressive environmental conditions, supporting sustainable construction practices.