Our objective is to develop quaternary cement binders and mortars by combining ordinary Portland cement (OPC) with supplementary cementitious materials (SCMs) including fly ash (FA), nano-silica (NS), and lime powder (LP) at replacement levels of 10 and 50%. The water–binder ratio was maintained at a constant value of 0.35 for all combinations. Testing was conducted on quaternary concrete to determine their strength and durability properties at ages of 7, 28, 56, and 90 days. Experiments were conducted to determine the compressive strength and rapid chloride permeability (RCPT) of quaternary concrete mixes. The objective of this study was to create a novel quaternary binder suitable for reducing our reliance on cement. Compared to the control binder, the related combinations of quaternary binders exhibited superior development in compressive strength. Combinations of 50% OPC + 30% FA + 15% LP + 5% NS in quaternary concrete resulted in superior improvement in compressive strength and permeability compared to other quaternary mortar with lime powder additive. Quaternary binders and mortars exhibit satisfactory overall performance for industrial use.