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Since performing our first heart transplant in May 1999, the National Cerebral and Cardiovascular Center (NCVC) has been actively involved in left ventricular assist device (LVAD) therapy and heart transplantation for patients with severe heart failure. This report presents the clinical outcomes of heart transplantation at NCVC and our current activities. The overall survival rates for heart transplantation at NCVC are 95%, 95%, and 87% at 5, 10, and 15 years, respectively, which are favorable compared to the International Society for Heart and Lung Transplantation (ISHLT) registry. While the number of heart transplants performed has been gradually increasing, the severe shortage of donors in Japan remains an ongoing issue, leading to prolonged waiting times for heart transplantation. Key challenges in managing prolonged wait times include strategies for bridging patients in cardiogenic shock to durable LVAD therapy, approaches to managing primary graft dysfunction, which is one of the leading causes of perioperative mortality, and aggressive utilization of marginal donors. We briefly discuss our current initiatives regarding these matters.

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Heart Transplantation in National Cerebral and Cardiovascular Center

  • 章节

  • 发表日期：

    2025年

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  • Satsuki Fukushima,
  • Kota Suzuki,
  • Yuji Tominaga,
  • Motoki Komori,
  • Satoshi Kainuma,
  • Yasumasa Tsukamoto,
  • Shigemitsu Iwai

摘要

Since performing our first heart transplant in May 1999, the National Cerebral and Cardiovascular Center (NCVC) has been actively involved in left ventricular assist device (LVAD) therapy and heart transplantation for patients with severe heart failure. This report presents the clinical outcomes of heart transplantation at NCVC and our current activities. The overall survival rates for heart transplantation at NCVC are 95%, 95%, and 87% at 5, 10, and 15 years, respectively, which are favorable compared to the International Society for Heart and Lung Transplantation (ISHLT) registry. While the number of heart transplants performed has been gradually increasing, the severe shortage of donors in Japan remains an ongoing issue, leading to prolonged waiting times for heart transplantation. Key challenges in managing prolonged wait times include strategies for bridging patients in cardiogenic shock to durable LVAD therapy, approaches to managing primary graft dysfunction, which is one of the leading causes of perioperative mortality, and aggressive utilization of marginal donors. We briefly discuss our current initiatives regarding these matters.