This research investigates the impact of nanofluid coolants on surface quality and tool wear during the turning of Ti6Al4V alloy. Machining Ti6Al4V, while desirable for its strength and corrosion resistance, is challenging due to its low thermal conductivity, high reactivity with tools, and propensity for work hardening, leading to accelerated tool wear, poor surface finishes, and reduced efficiency. This study explores the potential of nanofluids to mitigate these issues. Experimental results indicate that a hybrid nanofluid containing Al2O3 + CuO + MWCNTs nanoparticles exhibits superior performance compared to conventional coolants, yielding the best cylindrical and shoulder surface quality while minimizing flank and crater wear on the cutting tool. To determine the optimal turning parameters, the Technique for Order of Preference by Similarity to Ideal Solution method was employed. The analysis identified the following optimal parameters: a cutting speed of 60 m/min, a depth of cut of 0.8 mm, and a feed rate of 0.28 mm/rev. These findings highlight the potential of nanofluids to improve machining efficiency and surface integrity in the turning of Ti6Al4V alloy.