Piled rafts are subjected to combined vertical and lateral loadings in onshore, offshore, and marine environment conditions due to the action of earthquake, wave, lateral earth pressure, and wind in addition to gravity loading from the superstructures. The present study investigates the response of piled rafts subjected to combined vertical and lateral loadings from laboratory experiment and numerical analyses. The vertical load on the foundation has been applied as the fraction of ultimate load carrying capacity of the piled raft (Vmax) subjected to uniform vertical loading conditions. The experimental results have been compared with the results obtained from the numerical analyses. Parametric analysis has been performed on the prototype piled raft to study the influence of slenderness ratio and group area ratio on the foundation subjected to combined loadings. The lateral load carrying capacity of the piled raft increases in the range of 6–8%, 20–22%, 30–34%, 41–45%, and 46–53% with increasing vertical load from V = 0 to 0.1, 0.2, 0.3, 0.4, and 0.5 Vmax respectively for the parametric variations considered in the study. The results will be useful in developing insight into the lateral load carrying capacity of the piled raft subjected to combined loading. The paper describes the details of the experiment conducted, the numerical modeling procedure, material properties, parameters adopted in the analysis, and the results.