Personal protective equipment (PPE) is an important means of preventing work injuries. Ideally, the best approach is to maintain a safe work environment and eliminate any potential hazards. The use of PPE generally implies working in a potentially hazardous work environment and its use is a major means of injury prevention. Therefore, it is of prime importance to ensure that the equipment chosen is both reliable and effective; it is being properly used and maintained and the user has undergone adequate training. The aim of this paper is to raise the awareness of occupational safety and health practices and the proper use of PPE by people from all working of life. The PPE provides good defense against hazards of toxic exposure, dusting chemical splashes, steam water and liquids, flying particles, hot substances, radiation, sharp edges. Many fatal accidents are caused due to these reasons and use of appropriate PPE can prevent and lesson many of them. The final result of this paper is to ensure the greatest possible protection for employees in the workplace, the cooperative efforts of both employers and employees will help in establishing and maintaining a safe and healthful and fruitful work environment.