Advanced digital manufacturing technologies are currently under development in laboratories or specific fabrication environments. In the construction sector, numerous robotized processes are being experimented with, but their on-site implementation remains challenging. A potential solution is to decentralize production through modular laboratories or portable enclosures that can be brought to the execution site, enabling resource-savings and efficiency. Transformable enclosures allow flexibility in usage by providing shielding and security as well as accommodating design demands such as weatherproofing and noise, visual and splinter protection when needed. This project presents a concept of a hemispherical origami-based transformable and lightweight hybrid enclosure that can be applicable to robotic fabrication applications. Automated design processes implemented origami-based patterning techniques, identifying and adapting the origami pattern to gain full transformability. Static and dynamic analyses, as well as Multi-Body simulations, were carried out, to verify foldability and stability. The outcome is a realized construction of 2.3 m height, 4.15 m diameter that houses a robot with a 1.65 m range and a 15 kg payload demonstrating the feasibility of an origami-based enclosure system for architectural scale.