Inflammation is the body’s defense mechanism against infection and injury aimed at the localization and elimination of injurious agents, thus laying the foundation for the healing process to begin. It is a multistep process with the involvement of various cellular and humoral factors. The host tissue tries to revert to normal following inflammation through the process of repair. The two major methods of tissue repair are regeneration and repair by fibrosis or scar formation depending on the type of tissue injured. This chapter aims to highlight the major steps in the process of inflammation and healing.