The management of postharvest diseases in fruits and vegetables is imperative due to the significant value-added nature of these commodities and the substantial economic losses associated with spoilage. The utilization of synthetic fungicides is widely preferred on a global scale for the management of postharvest illnesses affecting fruits and vegetables. Nevertheless, these methods have been hindered by many issues and limitations, prompting researchers to devise new strategies for managing postharvest infections. Recently, nanomaterial treatments have shown encouraging outcomes, and they are being explored for their ability to decrease the use of synthetic fungicides for controlling postharvest rot in fruits and vegetables. Using copper-based nanomaterials in postharvest management signifies a pivotal shift in sustainable farming practices, epitomizing the transformative force of nanotechnology in agriculture. This paradigm shift, supported by ongoing research and technological advancements, holds promise for addressing global challenges in food security, resource efficiency, and environmental sustainability. In postharvest management, nanotechnology has emerged as a strategic tool for alleviating losses and optimizing supply chain efficiency. Realizing the full benefits of nanotechnology in agriculture requires sustained interdisciplinary collaboration and a responsible approach to implementation, ensuring both innovation and risk mitigation. The comprehensive content included in this chapter encompasses copper-based nanomaterials employed to manage postharvest decay.