The use of indigenous medicinal plants in Africa to address erectile dysfunction has gained significant attention, highlighting the efficacy of diverse plant species. This chapter presents a detailed documentation of medicinal plants utilized across Africa for managing erectile dysfunction, drawing insights from sources such as Scopus, Science Direct, Google Scholar, and grey literature. Factors like cultural preferences, geographical locations, and traditional beliefs influence the diagnosis, selection of potent plants, preparation methods, and administration for managing erectile dysfunction. The exact estimates of the prevalence of erectile dysfunction in Africa are difficult to ascertain, and estimates suggest rates exceeding 80% among hypertensive patients in public hospitals and 60% among diabetic patients. Erectile dysfunction is more prevalent in diabetic and hypertensive patients compared to those without these conditions. The documented medicinal plants are grouped into three categories: category 1 (n = 126) comprises plants lacking experimental research, category 2 (n = 44) includes plants studied experimentally, and category 3 (n = 8) covers plants investigated in clinical research. Studies exploring the use of medicinal plants from Africa, including ethnobotanical surveys, preclinical trials, and clinical investigations, underscore the potential of these plants in managing erectile dysfunction. These findings highlight the significant role of medicinal plants in addressing this global health concern.