MXenes, an emerging category of two-dimensional (2D) transition metal carbides, nitrides, and carbonitrides, have revolutionized the area of novel materials due to their remarkable features and numerous applications. Synthesized via selective etching of MAX layers using traditional conventional HF etching and innovative green fabrication methods, these materials exhibit high metallic conductivity, tunable surface chemistry, hydrophilicity, and robust mechanical strength aimed at minimizing environmental impact. The unique structure and surface functionalization of MXenes make them adaptable for diverse uses, including energy storage in supercapacitors and batteries, electromagnetic interference (EMI) shielding, water purification, catalysis, and biomedical applications. Their incorporation into composites and hybrid systems further enhances their functionality and broadens their industrial relevance. Recent advancements highlight their role in next-generation technologies, addressing scalability and long-term stability challenges. With over 40 MXenes structures fabricated to date and more than 100 theoretically predicted compositions, MXenes continue to attract researchers and show promise in emerging applications such as tribology. This chapter explores the fascinating realm of MXenes, focusing on their fabrication techniques, versatile applications, limitations, and prospects, especially in domains like biomedicine, energy storage, sensors, and catalysis. It highlights the evolution of these advanced 2D materials over the past decades and examines their transformative potential across diverse industries.