The Kaligandaki Road Corridor, a significant 442 km route in Nepal spanning from Gaidakot to Korala, is critical for regional connectivity but faces substantial slope stability challenges. This study presents a comprehensive analysis of slope stability along two key sections of the corridor—Balewa-Maldhunga and Harmichaur-Arbeni—using geotechnical and geophysical investigations. The methodology includes a three-phase approach: inception with desk research and preliminary surveys, investigation with detailed site analyses, and slope stability assessment using GEOSTUDIO 2018. Reconnaissance and drone surveys identified landslide-prone areas, while Electrical Resistivity Tomography (ERT) provided insights into subsurface conditions. Geotechnical investigations through boreholes revealed variations in soil and rock properties at both sites. The analysis indicates instability, with critical factors of safety falling below acceptable thresholds. Recommended stabilization measures include stepped gabion walls, sub-surface drains, and bioengineering techniques. The study underscores the integration of geotechnical and geophysical methods in assessing and mitigating slope instability, highlighting the need for enhanced monitoring and more extensive data collection in future research.