Computational Analysis of Hemodynamic Effects in Narrowed Human Coronary Artery Using Multiphase Mixture Model
摘要
The flow dynamics within the human arterial system pose a complex challenge, pivotal for understanding human physiology. Computational simulations of arterial blood flow offer insights into physiological processes, particularly in elucidating hemodynamic influences on arterial stenosis development and progression, crucial for cardiovascular health. Atherosclerosis, characterized by arterial narrowing due to cholesterol plaque accumulation, presents significant health risks including stroke, heart attacks, and cognitive decline. This study employs multiphase transient computational fluid dynamics (CFD) simulations to analyze pulsatile hemodynamics in stenosed rigid wall curved idealized human coronary artery segments. Notably, particulate deposition is observed along the inner curvature, consistent with previous studies. Investigating stenosis effects on pulsatile blood flow patterns using a multiphase mixture model reveals alterations in flow characteristics. Numerical calculations explore various physiological parameters, indicating a correlation between stenosis severity and hemodynamic alterations such as flow separation, axial and transverse velocities, and wall shear stress (WSS). Application of realistic pulsatile waveforms at the artery inlet enhances the study's physiological relevance. Findings highlight maximum WSS near the stenosis neck and minimum wall shear stress in the downstream of the stenosis underscoring the importance of stenosis severity in hemodynamic changes.