The present investigation aims to evaluate the advantages of employing minimum quantity lubrication (MQL) technique utilizing sunflower-based vegetable oil during grinding of AISI 52100 steel, using a patterned brazed microcrystalline cBN grinding wheel. Single-layer brazed cBN wheels have displayed considerable promise in grinding applications. The uniformly distributed patterned cBN wheels represent an enhancement over randomly distributed ones, as they can accommodate a larger volume of chips and effectively cut the material with a high material removal rate (MRR) while avoiding wheel loading issues. In dry grinding conditions, a significant amount of heat accumulates at the grinding interface, leading to a rapid increase in the temperature of the grinding zone. Furthermore, substantial friction forces arise due to the conversion of heat during sliding friction and the plowing process occurring between the cBN grits and the workpiece. This results in an elevated specific tangential and normal grinding force, increased specific energy consumption, and a rougher surface finish, especially at higher depths of cut. The utilization of MQL, specifically sunflower oil, proves to be an effective solution by providing satisfactory anti-friction and anti-wear properties. Notably, applying sunflower oil induces a more significant shearing effect on the chips than dry grinding conditions.