Silver nanoparticles (AgNPs) are one of the most commercially used nanomaterials having applications in products such as photonic devices, sensors, antimicrobial coatings, cosmetics, electronics, medical devices, water purifiers, molecular diagnostics, and, textiles. Usually, there are two approaches involved in AgNP synthesis accomplished by physical and chemical means. These techniques are expensive and sometimes even dangerous. Consequently, biological methods are preferred as they are cost-effective, eco-friendly, simple, and do not utilize toxic chemicals. Green synthesis of AgNPs is an emerging technique carried out by using different sources like bacteria, algae, fungi, and plants. As microorganisms pose the risk of contamination and lengthy procedures, plants are preferred. Therefore, in this study, five varieties of Ipomoea batatas leaves were used to synthesize AgNPs. These varieties Chitra, Dawala, CARI-09, CARI-426, and Wariyapola-White were collected from Peradeniya. Ipomoea batatas commonly known as sweet potatoes are generally planted for their tubers. Throughout harvesting, 95-98% of the leaves are disposed of while the surplus 2-5% is employed as animal feeds. The discarded leaves can be a promising source of natural antioxidants. Upon the addition of AgNO3 solution to leaf extract, pure Ag(I) ions reduce to Ag(0) in the presence of antioxidants. Total antioxidant capacity (TAC), total phenolic content (TPC), and total flavonoid content (TFC) of the synthesized AgNPs and their WEs were analyzed along with its antimicrobial detection. The synthesized AgNPs demonstrated a greater TPC and TAC, and lower TFC relative to their WEs. Furthermore, the biosynthesized AgNPs expressed a notable antimicrobial activity against Staphylococcus aureus and Escherichia Coli, where a higher activity was observed against gram-positive bacteria. Given the simplicity and non-toxic effects of synthesizing the AgNPs, it can be used for several applications to solve conventional problems that exist in the everyday world.