Inadequate wind load analysis often exposes low-rise buildings to significant wind damage, resulting in substantial economic losses. To address this issue, this study explores the role of boundary walls in mitigating wind-induced damages to gable roof, low-rise buildings. It aims to provide foundational guidance for constructing boundary walls that effectively reduce wind load impacts. Using Computational Fluid Dynamics (CFD) simulations, the research examines the influence of various boundary wall configurations on pressure distribution around such buildings. A total of twenty-six CFD models were developed and simulated, focusing on wind directions at 0° and 90°. These models encompass two distinct boundary wall arrangements (arrangement-1 and arrangement-2), two distances from the building (d/H = 1 and 2), and four wall heights (h/H = 0.33, 0.67, 1.00, and 1.33) relative to the building’s eave height (H). Model creation and meshing were performed using ANSYS Gambit, while ANSYS Fluent was employed for CFD simulations. The study primarily evaluated pressure coefficients (Cp) and uplift forces acting on the roof surfaces. The analysis revealed several critical insights. Regarding boundary wall height, the uplift force on the roof was generally lower than the base model for all configurations except when h/H = 1.33. Increasing the boundary wall distance from d/H = 1 to 2 consistently reduced the uplift force on the roof. Furthermore, arrangement-1 demonstrated minimizing uplift forces compared to arrangement-2. Notably, the configuration with arrangement-1, boundary wall distance of d/H = 2, and height of h/H = 0.67 relative to the building height exhibited the lowest uplift forces on both the upwind and downwind roof surfaces. These findings underscore the relationship between boundary wall configurations, pressure distribution patterns, and uplift forces on the roof, providing valuable insights into optimizing boundary wall designs to enhance roof protection against wind-induced damages.