The urban population is notably susceptible to extreme climate events, primarily due to the effects of urban heat islands. It is essential to take immediate procedures to control the emission of carbon dioxide and reduce the impacts of climate change to confirm human survival and progress. As a result, concepts such as biomimicry and sustainable strategies have grown throughout the years as the most feasible solution for urban climate change mitigation. Biomimicry involves designing solutions that take inspiration from the functional principles exhibited by organisms or ecosystems in nature. This study addresses the effectiveness of Biomimicry approaches in urban building construction as a viable solution for achieving climate change mitigation. In this study, a systematic literature review was conducted to ensure an unbiased synthesis of literature with high quality and efficiency. Given the need for an in-depth understanding of the concept of Biomimicry, a qualitative research approach was employed. Additionally, expert interviews were conducted as the primary method of data collection, following purposive and snowball sampling methods to validate the findings from the literature synthesis. Finally, a qualitative content analysis was utilized as the method of data analysis in this study. As a design and innovation approach inspired by nature’s strategies, Biomimicry promotes the development of sustainable architecture and urban environments, offering a possible solution for forming a more resilient, ecologically friendly urban built environment. This study comprehensively reviews how biomimicry is utilized in architecture to achieve efficient, sustainable built environments. It encourages a reflective approach to biologically inspired innovation to mitigate negative climate impact.