To maintain crop productivity, the use of pesticides becomes a crucial factor in present-day agricultural practices. In India, the Green Revolution indirectly encouraged pesticide use. Population efflux advocates for higher production of secured food. In India, to satisfy the needs of about 140 crore people, it is necessary to use pesticides and provide support. The global usage of pesticides in agriculture has increased steadily in the last couple of decades and reached 3.54 million metric tons in 2021. Though pesticide use becomes a prerogative for the production of target crops, it is reversed to environmental compliance. Though pesticides are applied to target crop production to ensure food security, these are considered hazardous environmental pollutants. It is for their persistence, mobility, long-term effects on the living system, and soil health. Merely 2–3% of the pesticides used to mitigate pests are effectively utilized at the target point. The remaining amount is leftovers, which come down to the environment and act as a source of pollutants that cause various health risks. Therefore, their exclusion from the environment or conversion into less hazardous compounds is advised. Various techniques of pesticide bioremediation are recommended depending on the crop type. However, managing the leftover pesticide through the microbial system is highly advisable since it is eco-, environment-, application-, and budget-friendly. Among the environmental microbes, actinobacteria are leading colonizers and thus ubiquitous. They are sufficiently metabolically enriched to harbor many enzymes having great catabolic activities for the conversion/transformation of hazardous chemicals. The strains belonging to the various genera of actinobacteria, including Arthrobacter, Nocardioides, Streptomyces, Frankia, and Rhodococcus, are rigorously attempted with commonly used pesticides, such as atrazine, chlorpyrifos, carbendazim, deltamethrin, cypermethrin, and lindane, which are noteworthy. An attempt has been made to make the next generation of scientists accelerate research on pesticide bioremediation, considering actinobacteria as a model.