Homogeneous catalysis involving group 10 metals has become highly significant in various coupling reactions, such as Heck, Stille, Suzuki and Sonogashira. These coupling reactions enable the synthesis of a wide array of products, either for the first time or with much greater efficiency than previously possible. This type of catalysis is characterized by high reaction rates and high turnover numbers (TON), and often results in high selectivity and yields. Moreover, the catalytic activity of these complexes can be modulated by ligands. Effective ligand design has produced catalysts that exhibit increased TON and reaction rates, and maintain stability at lower reaction temperatures. This manuscript provides a concise overview of the design and synthesis of group 10-based molecular materials used as homogeneous catalysts in various coupling reactions. It discusses the synthetic methodologies employed to develop these efficient catalysts and highlights the crucial role of in situ formation of group 10 nanomaterials in catalysis.