Activating the C–H bond to value-added chemicals is a great challenge to the research community in heterogeneous catalysis. Exploiting the enormous shale gas reserves aided the natural gas production and supply surge, mainly methane. These activities have impacted fueling GHG emissions over past decades. Due to the highly stable C–H bond, tuning of catalyst properties for activating is of significant interest. Tailoring of the catalyst can be done by having a mechanistic insight into the intermediates being formed during the transition state of any reaction pathway. In this chapter, we systematically evaluated the progress in both reforming and oxidative coupling reactions involving the bond activation in lower alkanes, the processes used for the conversion of methane to commercially valued products. While the latter part is followed by a discussion of the global demand and the need to find alternative synthesis techniques for adipic acid. This platform chemical could be done by using cyclohexane as a starting compound. Greener and sustainable pathways have opened a new domain for novel catalytic processes which can be economically viable. This chapter enlightens on overcoming challenges imposed by the traditional methods and improvising on using heterogeneous catalytic processes mainly for large-scale production.