To further verify the applicability of the stability optimization design method, this chapter takes two practically constructed large single-layer lattice shell structures used for shaking table collapse experiments as examples to carry out stability optimization design. Each lattice shell structure has as many as 3660 bars, with a very large number of optimization variables. The candidate bar section ranges from outer diameter 18 mm to outer diameter 114 mm, with a similarly large number of candidate bars. The support conditions, topological connections and steel consumption of the two lattice shell structures are completely the same, but Model 1 is a perfect structure with uniform stiffness, while Model 2 is a weak model with artificially set weak areas and stiffness redundancy areas. The two practical models are optimized and the optimization results are compared to further verify the stability optimization design method. The actual built models 1 and 2 were subjected to shaking table collapse experiments. In order to verify the collapse resistance ability of the stabilized and optimized structure, the same seismic wave was input into the two optimized lattice shell structures through numerical simulation, and the display dynamic algorithm was used to study the collapse resistance ability of the stabilized and optimized structure. The checking results show that the stabilized and optimized structure not only has good static stability performance, but also has good collapse resistance performance.