Seven coronaviruses are of relevance to human diseases. 229 E, NL63, OC43, and HKU1 would have infected the human population with common cold, but SARS (Severe Acute Respiratory Syndrome), MERS (Middle-East Respiratory Syndrome), and SARS-2 have major implications for human health and mortality. These viral infections have visited, almost every decade, since the millennium, starting the year 2000. In particular, SARS-2 has been a major unprecedented affliction with over 768 million infections and 6.9 million deaths, reported to WHO. SARS-2 was first reported in Wuhan, China, in late December 2019. Vaccines have played a major role in limiting severe diseases and deaths, although the virus has been able to infect. COVID-19 vaccines are widely credited to have prevented an additional 14.14 and 19.8 million deaths during December 8, 2020 to December 8, 2021 in 185 countries [8].