Traditional implants and prostheses have a variety of drawbacks, such as inflammation of tissues surrounding the implant, osteolysis, lack of osseointegration, metal allergies, and implant breakage, which eventually lead to long-term damage to patients’ health. However, rapid advancements in technology have revolutionized the medical field. Integrating nanotechnology and nanomaterial in implants offers an innovative solution to overcome these drawbacks. Among these technologies, nanocoatings play a considerable role in improving the performance of implants. These coatings are mainly used for surface modification to enhance mechanical strength and biocompatibility and reduce stress shielding. Introducing antimicrobial materials in the implants protects against microbes and prevents cytotoxicity. Nanomaterials have recently been integrated into orthopedic implants and prostheses, enhancing wear resistance and bioactivity to increase osseointegration and strong mechanical strength. Additionally, 3D-printed implants offer material and design personalization to the patients. Furthermore, nanostructure modifications and coatings have been incorporated into dental implants that can improve antimicrobial activity. Nanomaterials enhance their durability and seamless drug delivery in cardiovascular implants like stents and pacemakers. This chapter provides a comprehensive review of the integration of nanotechnology with orthopedic, dental, and cardiovascular implants and prostheses. This chapter highlights the state-of-the-art technological advancements in these implants and how they have revolutionized the medical field.