A worldwide issue is the significant release of greenhouse gases from industrial waste. The severity of the problem is increased by the non-biodegradable nature of industrial wastes, namely glass and silica fume. According to earlier research, an effective way to keep natural resources from going extinct would be to use waste materials in the cement and construction industries. Several approaches have been made to replace supplemental cementitious materials (SCMs), which can improve the performance of the concrete produced for cement in light of the detrimental environmental effects of the cement manufacturing process. This research investigates the effect of replacing cement with silica fume and glass powder on the properties of concrete, emphasising mechanical characteristics. The experimental investigation involves the assessing mechanical properties of concrete, namely compressive strength, split tensile strength, and flexural strength by casting and testing of cube, cylinder, and beam specimens of M25 grade concrete with cement being replaced by silica fume and glass powder combined at the percentage of (0 + 0%), (5 + 5%), (10 + 10%), (15 + 15%), and (20 + 20%) by weight of cement. The obtained test results indicate that (15 + 15%) replacement of combined silica fume and glass powder has improved the characteristics as compared to the reference mix. This study focuses on providing valuable insights for engineers, researchers, and practitioners seeking sustainable alternatives in the construction industry.